Detalhe da pesquisa
1.
A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Nucleic Acids Res
; 52(4): 1661-1676, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38084912
2.
Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Proc Natl Acad Sci U S A
; 120(10): e2217804120, 2023 03 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36848571
3.
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Nucleic Acids Res
; 50(6): 3254-3275, 2022 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35212371
4.
Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond.
Drug Metab Dispos
; 51(2): 228-236, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36116789
5.
Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning.
Cell Mol Life Sci
; 78(1): 317-335, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32232515
6.
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
J Am Chem Soc
; 143(44): 18467-18480, 2021 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648292
7.
CITCO Directly Binds to and Activates Human Pregnane X Receptor.
Mol Pharmacol
; 97(3): 180-190, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31882411
8.
3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H.
Antimicrob Agents Chemother
; 61(6)2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320718
9.
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.
Antimicrob Agents Chemother
; 61(10)2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28760905
10.
4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms.
J Biol Chem
; 289(35): 24533-48, 2014 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24970894
11.
SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 58(8): 4915-9, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24867973
12.
Regulation of PXR in drug metabolism: chemical and structural perspectives.
Expert Opin Drug Metab Toxicol
; 20(1-2): 9-23, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38251638
13.
Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR.
Nat Commun
; 15(1): 4054, 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38744881
14.
CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer.
Genes Dis
; 11(4): 101079, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38560501
15.
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.
Retrovirology
; 10: 65, 2013 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23800377
16.
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.
Structure
; 31(12): 1545-1555.e9, 2023 12 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37729916
17.
Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus.
Viruses
; 15(4)2023 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37112961
18.
The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation.
Acta Pharm Sin B
; 13(11): 4523-4534, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37969738
19.
SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.
ACS Med Chem Lett
; 13(8): 1311-1320, 2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35978691
20.
Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.
J Med Chem
; 63(3): 1415-1433, 2020 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31965799